Gene expression signatures in tree shrew choroid during lens-induced myopia and recovery
نویسندگان
چکیده
منابع مشابه
Alterations in protein expression in tree shrew sclera during development of lens-induced myopia and recovery.
PURPOSE During the development of, and recovery from, negative lens-induced myopia there is regulated remodeling of the scleral extracellular matrix (ECM) that controls the extensibility of the sclera. Difference gel electrophoresis (DIGE) was used to identify and categorize proteins whose levels are altered in this process. METHODS Two groups of five tree shrews started monocular lens wear 2...
متن کاملDifferential protein expression in Tree Shrew sclera during development of lens-induced myopia and recovery
PURPOSE The tree shrew model of refractive development is particularly useful because, like humans, tree shrews have a fibrous sclera. Selective changes in some candidate extracellular matrix proteins and mRNAs have been found in the sclera during the development of and recovery from induced myopia. We undertook a more neutral proteomic analysis using two-dimensional gel electrophoresis and mas...
متن کاملScleral gene expression during recovery from myopia compared with expression during myopia development in tree shrew
PURPOSE During postnatal refractive development, the sclera receives retinally generated signals that regulate its biochemical properties. Hyperopic refractive error causes the retina to produce "GO" signals that, through the direct emmetropization pathway, cause scleral remodeling that increases the axial elongation rate of the eye, reducing the hyperopia. Myopia causes the retina to generate ...
متن کاملModulation of glycosaminoglycan levels in tree shrew sclera during lens-induced myopia development and recovery.
PURPOSE In juvenile tree shrews, positioning a negative-power lens in front of an eye produces a hyperopic shift in refractive state and causes a compensatory increase in axial length over several days so that the eye is myopic when the lens is removed. During negative lens compensation, the scleral extracellular matrix is remodeled. A biomechanical property of the sclera, creep rate, increases...
متن کاملGene expression signatures in tree shrew choroid in response to three myopiagenic conditions
We examined gene expression in tree shrew choroid in response to three different myopiagenic conditions: minus lens (ML) wear, form deprivation (FD), and continuous darkness (DK). Four groups of tree shrews (n=7 per group) were used. Starting 24 days after normal eye opening (days of visual experience [DVE]), the ML group wore a monocular -5D lens for 2 days. The FD group wore a monocular trans...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2014
ISSN: 0014-4835
DOI: 10.1016/j.exer.2014.04.005